Blar i forfatter "Corbett, Elizabeth L."

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    • Azithromycin versus placebo for the treatment of HIV-associated chronic lung disease in children and adolescents (BREATHE trial): study protocol for a randomised controlled trial 

      Gonzalez-Martinez, Carmen; Kranzer, Katharina; McHugh, Grace; Corbett, Elizabeth L.; Mujuru, Hilda A.; Nicol, Mark P; Rowland-Jones, Sarah; Rehman, Andrea M.; Gutteberg, Tore Jarl; Flægstad, Trond; Odland, Jon Øyvind; Ferrand, Rashida (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Background<br> Human immunodeficiency virus (HIV)-related chronic lung disease (CLD) among children is associated with substantial morbidity, despite antiretroviral therapy. This may be a consequence of repeated respiratory tract infections and/or dysregulated immune activation that accompanies HIV infection. Macrolides have anti-inflammatory and antimicrobial properties, and we hypothesised that ...

    • Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial 

      Ferrand, Rashida A.; McHugh, Grace; Rehman, Andrea M.; Mujuru, Hilda A.; Simms, Victoria; Majonga, Edith D.; Nicol, Mark P.; Flægstad, Trond; Gutteberg, Tore Jarl; Gonzalez-Martinez, carmen; Corbett, Elizabeth L.; Rowland-Jones, Sarah; Kranzer, Katharina; Weiss, Helen Anne; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)
      <i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ...

    • Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi 

      Kaswaswa, Kruger; MacPherson, Peter; Kumwenda, Moses; Mpunga, James; Thindwa, Deus; Nliwasa, Marriott; Mwapasa, Mphatso; Odland, Jon Øyvind; Tomoka, Tamiwe; Chipungu, Geoffrey; Mukaka, Mavuto; Corbett, Elizabeth L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      <p><b> Background</b> Household contact tracing provides TB screening and TB preventive therapy (TPT) to contacts at high risk of TB disease. However, it is resource intensive, inconvenient, and often poorly implemented. We investigated a novel model aiming to improve uptake. <p><b> Methods</b> Between May and December 2014, we randomised patient with TB who consented to participate in the ...

    • High HIV and active tuberculosis prevalence and increased mortality risk in adults with symptoms of TB: a systematic review and meta-analyses 

      Nliwasa, Marriot; MacPherson, Peter; Gupta-Wright, Ankur; Mwapasa, Mphatso; Horton, Katherine; Odland, Jon Øyvind; Flach, Clare; Corbett, Elizabeth L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-31)
      <i>Introduction</i>: HIV and tuberculosis (TB) remain leading causes of preventable death in low- and middle-income countries(LMICs). The World Health Organization (WHO) recommends HIV testing for all individuals with TB symptoms, but implementation has been suboptimal. We conducted a systematic literature review and meta-analyses to estimate HIV and TB prevalence, and short-term (two to six months) ...